Phosphofructo 2-kinase/fructose 2, 6-bisphosphatase 3 (PFKFB3) has been reported to be
overexpressed in human cancer tissues and to promote the proliferation and migration of …

Breast cancer is a highly heterogeneous disease. Although differences between intrinsic
breast cancer subtypes have been well studied, heterogeneity within each subtype …

Background Progression to stage IV disease remains the main cause of breast cancer-
related deaths. Increasing knowledge on the hematogenous phase of metastasis is key for …

Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related mortality with
a dismal prognosis that has changed little over the past few decades. Further understanding …

Abstract Trefoil factor 3 (TFF3, also known as intestinal trefoil factor) is a small-molecule
peptide containing a typical trefoil structure. TFF3 has several biological effects, such as …

The efficacious treatment of hepatocellular carcinoma (HCC) remains a challenge, partially
being attributed to intrinsic chemoresistance. Previous reports have observed increased …

The epidermal growth factor receptor (EGFR) is a validated therapeutic target for triple-
negative breast cancer (TNBC). In the present study, we synthesize novel adamantanyl …

The overexpression of trefoil factor family 3 (TFF3) is observed in a variety of cancers,
including prostate cancer (PCa), and its potential role in carcinogenesis, such as activating …

Platycodin D is a major constituent in the root of Platycodon grandiflorum and has diverse
pharmacologic activities, including anti-inflammatory, anti-allergic, and antitumor activities …

The development of alternative methods to animal testing is a priority in the context of
regulatory toxicology. Carcinogenesis is a field where the demand for alternative methods is …