Genetics of human brain development

Y Zhou, H Song, G Ming - Nature Reviews Genetics, 2024 - nature.com
Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Comprehensive cell atlas of the first-trimester developing human brain

E Braun, M Danan-Gotthold, LE Borm, KW Lee… - Science, 2023 - science.org
The adult human brain comprises more than a thousand distinct neuronal and glial cell
types, a diversity that emerges during early brain development. To reveal the precise …

Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: reconciling controversy or fueling the debate?

G Tosoni, D Ayyildiz, J Bryois, W Macnair… - Neuron, 2023 - cell.com
The notion of exploiting the regenerative potential of the human brain in physiological aging
or neurological diseases represents a particularly attractive alternative to conventional …

Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development

F Jiang, X Zhou, Y Qian, M Zhu, L Wang, Z Li, Q Shen… - Nature …, 2023 - nature.com
The brain is a complex tissue whose function relies on coordinated anatomical and
molecular features. However, the molecular annotation of the spatial organization of the …

Publicly available ex vivo transcriptomics datasets to explore CNS physiology and neurodegeneration: state of the art and perspectives

S Abdullatef, C Farina - Frontiers in Neuroscience, 2023 - frontiersin.org
The central nervous system (CNS) is characterized by an intricate composition of diverse
cell types, including neurons and glia cells (astrocytes, oligodendrocytes, and microglia) …

How developmental cell atlases inform stem cell embryo models

M Haniffa, A Maartens, SA Teichmann - Nature Methods, 2023 - nature.com
How developmental cell atlases inform stem cell embryo models | Nature Methods Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

A molecular and cellular perspective on human brain evolution and tempo

FW Lindhout, FM Krienen, KS Pollard, MA Lancaster - Nature, 2024 - nature.com
The evolution of the modern human brain was accompanied by distinct molecular and
cellular specializations, which underpin our diverse cognitive abilities but also increase our …

Neural cell diversity in the light of single-cell transcriptomics

SM Fernández-Moya, AJ Ganesh, M Plass - Transcription, 2023 - Taylor & Francis
The development of highly parallel and affordable high-throughput single-cell
transcriptomics technologies has revolutionized our understanding of brain complexity …

STAB2: an updated spatio-temporal cell atlas of the human and mouse brain

YT Yang, Z Gan, J Zhang, X Zhao, Y Yang… - Nucleic Acids …, 2024 - academic.oup.com
The brain is constituted of heterogeneous types of neuronal and non-neuronal cells, which
are organized into distinct anatomical regions, and show precise regulation of gene …

Heterogeneity and developmental dynamics of mammalian neocortical progenitors

LHA Alieh, A Herrera, G La Manno - Current Opinion in Systems Biology, 2023 - Elsevier
The central nervous system develops from a pool of neural progenitors which, depending on
their location and time of division, generate cells committed to differentiate into specific kinds …