Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Clinical use of doxorubicin (DOX) is limited because of its cardiotoxicity, referred to as DOX-
induced cardiomyopathy (DIC). Mitochondria-dependent ferroptosis, which is triggered by …

Biological energy transduction underlies all physiological phenomena in cells. The
metabolic systems that support energy transduction have been of great interest due to their …

Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …

Enormous strides have recently been made in our understanding of the biology and
pathobiology of mitochondria. Many diseases have been identified as caused by …

Mitochondrial dysfunction is central to numerous diseases of oxidative stress. Changes in
mitochondrial DNA (MtDNA) content, often measured as mitochondrial genome to nuclear …

Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of
human diseases. Identifying all of the proteins resident in this organelle and understanding …

Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the
majority of cell types. Here we review the sources and metabolism of ROS in this organelle …

Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of
model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1 …