Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Pancreatic β cells are mostly post-mitotic, but it is unclear what locks them in this state.
Perturbations including uncontrolled hyperglycemia can drive β cells into more pliable states …

Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

Blood–brain barrier (BBB) breakdown and inflammation occurring at the BBB have a key,
mainly a deleterious role in the pathophysiology of ischemic stroke. Neddylation is a …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Neddylation is one type of protein post‐translational modification by conjugating a ubiquitin‐
like protein neural precursor cell‐expressed developmentally downregulated protein 8 to …

Background Endothelial dysfunction and arterial stiffening play major roles in cardiovascular
diseases. The critical role for the miR-181 family in vascular inflammation has been …

Atherosclerosis (AS) is a chronic metabolic disorder and primary cause of cardiovascular
diseases, resulting in substantial morbidity and mortality worldwide. Initiated by endothelial …

Vascular aging refers to the structural and functional defects that occur in the aorta during
the aging process and is characterized by increased vascular cell senescence, vascular …