Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular
carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia …

Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose
for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family …

Liver cancer most commonly develops in patients with chronic liver disease, the etiology of
which includes viral hepatitis (B and C), alcohol, obesity, dietary carcinogens, and so forth …

In most cases, sorafenib-resistant HCC cells exhibit significant mesenchymal phenotype and
stemness features. In this context, tumor cells might undergo cell fate transition in response …

Cancer cells voraciously consume nutrients to support their growth, exposing metabolic
vulnerabilities that can be therapeutically exploited. Here, we show in hepatocellular …

Tumor microenvironment (TME), which is characterized by hypoxia, widely exists in solid
tumors. As a current research hotspot in the TME, hypoxia is expected to become a key …

Sorafenib is a multi-kinase inhibitor and one of the few systemic treatment options for
patients with advanced hepatocellular carcinomas (HCCs). Resistance to sorafenib …

In the 1920s, Otto Warburg observed the phenomenon of altered glucose metabolism in
cancer cells. Although the initial hypothesis suggested that the alteration resulted from …

Aerobic glycolysis is a well‐known hallmark of hepatocellular carcinoma (HCC). Hence,
targeting the key enzymes of this pathway is considered a novel approach to HCC treatment …

Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various
microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by …