An overview of 1, 2, 3-triazole-containing hybrids and their potential anticholinesterase activities
Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
Benzofuran and indole: promising scaffolds for drug development in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
A comprehensive review of cholinesterase modeling and simulation
D De Boer, N Nguyen, J Mao, J Moore, EJ Sorin - Biomolecules, 2021 - mdpi.com
The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …
butyrylcholinesterase structure and function using computer-based modeling and simulation …
Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review
Quinazolines are considered as a promising class of bioactive heterocyclic compounds with
broad properties. Particularly, the quinazoline scaffold has an impressive role in the design …
broad properties. Particularly, the quinazoline scaffold has an impressive role in the design …
2, 4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity …
A library of fifty-seven 2, 4-disubstituted quinazoline derivatives were designed, synthesized
and evaluated as a novel class of multi-targeting agents to treat Alzheimer's disease (AD) …
and evaluated as a novel class of multi-targeting agents to treat Alzheimer's disease (AD) …
In silico modeling for dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes in Alzheimer's disease
In this research, we have implemented two-dimensional quantitative structure-activity
relationship (2D-QSAR) modeling using two different datasets, namely, acetylcholinesterase …
relationship (2D-QSAR) modeling using two different datasets, namely, acetylcholinesterase …
Synthesis and biological evaluation of novel quinazoline-triazole hybrid compounds with potential use in Alzheimer's disease
G Le-Nhat-Thuy, NN Thi, H Pham-The, TAD Thi… - Bioorganic & Medicinal …, 2020 - Elsevier
A library of twelve quinazoline-triazole hybrid compounds were designed, synthesized and
evaluated as a novel class of acetylcholinesterase inhibitors to treat Alzheimer's disease …
evaluated as a novel class of acetylcholinesterase inhibitors to treat Alzheimer's disease …
Synthesis, biological evaluation and docking studies of 2, 3-dihydroquinazolin-4 (1H)-one derivatives as inhibitors of cholinesterases
In search of potent inhibitors of cholinesterases, we have synthesized and evaluate a
number of 2, 3-dihydroquinazolin-4 (1H)-one derivatives. The synthetic approach provided …
number of 2, 3-dihydroquinazolin-4 (1H)-one derivatives. The synthetic approach provided …
[HTML][HTML] Synthesis, characterization, biological evaluation, and kinetic study of indole base sulfonamide derivatives as acetylcholinesterase inhibitors in search of …
Alzheimer is a prolonged neurodegenerative disease which degenerate the brain cells and
particularly affects the person ability to function independently. Despite of dynamic research …
particularly affects the person ability to function independently. Despite of dynamic research …
Thiadiazole–A promising structure in design and development of anti-Alzheimer agents
M Hatami, Z Basri, BK Sakhvidi, M Mortazavi - International …, 2023 - Elsevier
The design and development of effective multitargeted agents in treating Alzheimer disease
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …