Beyond hemostasis: platelet innate immune interactions and thromboinflammation

J Mandel, M Casari, M Stepanyan, A Martyanov… - International journal of …, 2022 - mdpi.com
There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …

Platelet–neutrophil interactions as drivers of inflammatory and thrombotic disease

T Lisman - Cell and tissue research, 2018 - Springer
Neutrophils are well known for their role in infection and inflammatory disease and are first
responders at sites of infection or injury. Platelets have an established role in hemostasis …

Measuring and interpreting platelet-leukocyte aggregates

M Finsterbusch, WC Schrottmaier, JB Kral-Pointner… - Platelets, 2018 - Taylor & Francis
Platelets, besides their specialised role in haemostasis and atherothrombosis, actively
modulate innate and adaptive immune responses with crucial roles in immune surveillance …

Platelets in inflammation: regulation of leukocyte activities and vascular repair

A Gros, V Ollivier, B Ho-Tin-Noé - Frontiers in immunology, 2015 - frontiersin.org
There is now a large body of evidence that platelets are central actors of inflammatory
reactions. Indeed, platelets play a significant role in a variety of inflammatory diseases …

Platelets: a critical link between inflammation and microvascular dysfunction

KY Stokes, DN Granger - The Journal of physiology, 2012 - Wiley Online Library
Inflammation is an underlying feature of a variety of human diseases. An important
manifestation of this pathophysiological response is microvascular dysfunction, which …

Platelet–leukocyte interactions in cardiovascular disease and beyond

L Totani, V Evangelista - Arteriosclerosis, thrombosis, and vascular …, 2010 - Am Heart Assoc
Platelet–leukocyte interactions define a basic cell process that is characterized by the
exchange of signals between platelets and different types of leukocytes and that bridges 2 …

The role of glycosylation in IBD

E Theodoratou, H Campbell, NT Ventham… - Nature reviews …, 2014 - nature.com
A number of genetic and immunological studies give impetus for investigating the role of
glycosylation in IBD. Experimental mouse models have helped to delineate the role of …

Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation

C Page, S Pitchford - International immunopharmacology, 2013 - Elsevier
The manifestation of platelet 'satallitism'around neutrophils in whole blood is a long
acknowledged phenomenon [1]. Circulating platelet–neutrophil complexes (PNC) occur in a …

Platelet activation markers in evaluation of thrombotic risk factors in various clinical settings

M Kannan, F Ahmad, R Saxena - Blood reviews, 2019 - Elsevier
Platelets play a major role in primary hemostasis and thrombus formation. After vascular
injury, platelets adhere to injured site and rapidly change their shape that switches the …

Characterization of serum cytokine profile in predominantly colonic inflammatory bowel disease to delineate ulcerative and Crohn's colitides

OY Korolkova, JN Myers, ST Pellom… - Clinical Medicine …, 2015 - journals.sagepub.com
Background As accessible diagnostic approaches fail to differentiate between ulcerative
colitis (UC) and Crohn's colitis (CC) in one-third of patients with predominantly colonic …