Early-onset colorectal cancer (EOCRC) has seen an alarming rise worldwide over the past
two decades. The reason for this global trend is poorly understood. EOCRC appears to have …

Colorectal cancer is one of the most common tumors, and genetic predisposition is one of
the key risk factors in the development of this malignancy. Lynch syndrome and familial …

Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …

Around 10% to 16% 1–4 of all individuals with colorectal cancer have a pathogenic variant
in a cancer susceptibility gene (Table 1). While not all of these genes have been associated …

Simple Summary Early-onset colorectal cancer is increasing in incidence in the United
States, and it is expected to more than double in the next 10 years. There are many risk …

Background Inheritance patterns show familial clustering of gastrointestinal cancers, and
multiple germline conditions have now been identified that predispose to colorectal, gastric …

Abstract Early Onset Colorectal cancer (EOCRC) incidence is increasing at an alarming
pace. An increase of 90% in colon cancer and 124% in rectal cancer is expected by 2030 …

Colorectal cancer is the most common cancer in Saudi males and the second most common
cancer in Saudi females with increasing incidence throughout the last four decades …

Background The unexplained rise of young-onset CRC (yoCRC, age< 50 years) is of
concern. Evidence suggests that microbial dysbiosis may be a contributing factor, but the …

Early-onset colorectal cancer (age under 50 years)(EOCRC) is an entity of undeniable
importance, both because of its growing incidence, and the population it affects. Other …