Targeted protein degradation (TPD) mediates protein level through small molecule induced
redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal …

WDR5 is a conserved nuclear protein that scaffolds the assembly of epigenetic regulatory
complexes and moonlights in functions ranging from recruiting MYC oncoproteins to …

MYC, as a well-known oncogene, plays essential roles in promoting tumor occurrence,
development, invasion and metastasis in many kinds of solid tumors and hematologic …

The conserved WD40-repeat protein WDR5 interacts with multiple proteins both inside and
outside the nucleus. However, it is currently unclear whether and how the distribution of …

Metastatic breast cancer remains a major cause of cancer-related deaths in women, and
there are few effective therapies against this advanced disease. Emerging evidence …

Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations
of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC …

WD40 Repeat Domain 5 (WDR5) is a highly conserved nuclear protein that recruits MYC
oncoprotein transcription factors to chromatin to stimulate ribosomal protein gene …

Transcription factors often interact with other protein cofactors, regulating gene expression.
Direct detection of these brief events using existing technologies remains challenging due to …

WD40 repeat proteins are frequently involved in processing cell signaling and scaffolding
large multi-subunit machineries. Despite their significance in physiological and disease-like …

WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context
in a range of chromatin-centric processes. WDR5 is also a prominent target for …