RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release

S Kim, S Tan, J Ku, TA Widowati, D Ku, K Lee, K You… - Molecular Cell, 2024 - cell.com
Mitochondria are essential regulators of innate immunity. They generate long mitochondrial
double-stranded RNAs (mt-dsRNAs) and release them into the cytosol to trigger an immune …

Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle

Y Choi, B Um, Y Na, J Kim, JS Kim, VN Kim - Molecular Cell, 2024 - cell.com
Summary mRNAs continually change their protein partners throughout their lifetimes, yet our
understanding of mRNA-protein complex (mRNP) remodeling is limited by a lack of temporal …

The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

I Ensinck, A Maman, WS Albihlal, M Lassandro… - Elife, 2023 - elifesciences.org
Abstract N6-methyladenosine (m6A), the most abundant mRNA modification, is deposited in
mammals/insects/plants by m6A methyltransferase complexes (MTC) comprising a catalytic …

Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling

NS Kejiou, L Ilan, S Aigner, E Luo, T Tonn… - Nucleic acids …, 2023 - academic.oup.com
In light of the numerous studies identifying post-transcriptional regulators on the surface of
the endoplasmic reticulum (ER), we asked whether there are factors that regulate …

The RNA-binding protein landscapes differ between mammalian organs and cultured cells

JI Perez-Perri, D Ferring-Appel, I Huppertz… - Nature …, 2023 - nature.com
Abstract System-wide approaches have unveiled an unexpected breadth of the RNA-bound
proteomes of cultured cells. Corresponding information regarding RNA-binding proteins …

Photoactivatable ribonucleosides mark base-specific RNA-binding sites

JW Bae, S Kim, VN Kim, JS Kim - Nature Communications, 2021 - nature.com
RNA-protein interaction can be captured by crosslinking and enrichment followed by tandem
mass spectrometry, but it remains challenging to pinpoint RNA-binding sites (RBSs) or …

Role of Y-Box Binding Proteins in Ontogenesis

DA Kretov - Biochemistry (Moscow), 2022 - Springer
Y-box binding proteins (YB proteins) are multifunctional DNA/RNA-binding proteins capable
of regulating gene expression at multiple levels. At present, the most studied function of …

Proteomic Profiling of Messenger Ribonucleoproteins in Mouse Tissues Based on Formaldehyde Cross-Linking

J Wang, J Liu, R Huang, T Chu, Q Tang… - Journal of Proteome …, 2024 - ACS Publications
Messenger ribonucleoprotein particles (mRNPs) are vital for tissue-specific gene expression
via mediating posttranscriptional regulations. However, proteomic profiling of proteins in …

Protein-RNA interaction dynamics reveal key regulators of oncogenic KRAS-driven cancers

KY Ban, Y Na, J Song, JS Kim, J Kim - Scientific Reports, 2024 - nature.com
KRAS is one of the most frequently mutated oncogenes across various cancers. Oncogenic
KRAS mutations rewire cellular signaling, leading to significant alterations in gene …

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

A Kshirsagar, SM Doroshev, A Gorelik… - Nature …, 2023 - nature.com
Abstract Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is
known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 …