Most cancer-related deaths are a result of metastasis, and thus the importance of this
process as a target of therapy cannot be understated. By asking 'how can we effectively treat …

MYC is a master transcriptional regulator that controls almost all cellular processes. Over the
last several decades, researchers have strived to define the context-dependent …

Purpose: Bromodomain and extraterminal (BET) proteins play important roles in
transcriptional regulation relevant to cancer pathogenesis, and therapeutic …

Hydrogels prepared from natural polymer have attracted extensive attention in biomedical
fields such as drug delivery, wound healing, and regenerative medicine due to their good …

The dominant paradigm in drug discovery is to design ligands with maximum selectivity to
act on individual drug targets. With the target-based approach, many new chemical entities …

The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists
of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer …

Abstract The Bromodomain and Extra-terminal (BET) family of proteins were first recognized
as important epigenetic regulators in inflammatory processes; however, there is increasing …

Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the
neural crest and accounts for more than 15% of all the childhood deaths from cancer. The …

Cancer immunotherapy, including immune checkpoint blockade and adoptive CAR T‐cell
therapy, has clearly established itself as an important modality to treat melanoma and other …

Neuroblastoma is the most common extracranial pediatric tumor and often presents with
metastatic disease, and patients with high-risk neuroblastoma have survival rates of~ 50 …