DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …

Alcohol drinking is a known risk factor for laryngeal cancer. However, little information is
available on the risk associated with light alcohol drinking. To address this issue, we …

Background Single nucleotide polymorphism (SNP) is a genetic variation that occurs when a
single nucleotide base in the DNA sequence varies between individuals and is present in at …

Lead is still widely used in many industrial processes and is very persistent in the
environment. Although toxic effects caused by occupational exposure to lead have been …

Cells experience both endogenous and exogenous DNA damage daily. To maintain
genome integrity and suppress tumorigenesis, individuals have evolutionarily acquired a …

Cell division cycle associated 2 (CDCA2) recruits protein phosphatase 1 to chromatin to
antagonize activation of ataxia telangiectasia mutated (ATM)-dependent signal transduction …

Background: Exposure to the same environmental factors in different people have resulted
in different susceptibility to head and neck squamous cell carcinoma (HNSCC), which …

Head and neck squamous cell carcinomas (HNSCC) are a heterogenous group of tumors
with a high rate of early recurrences, second primary tumors, and mortality. Despite …

Polymorphisms of LIG4 gene may influence DNA repair ability, thus altering the genetic
stability and resulting in carcinogenesis. A growing number of studies have investigated the …

Introduction: Normal function of DNA repair system is essential for the removal of damage
induced by many kinds of internal and environmental agents. Genetic polymorphisms in …