Cholesterol has gained tremendous attention as an essential lipid in the life cycle of virtually
all viruses. These seem to have developed manifold strategies to modulate the cholesterol …

The mitochondrial antiviral signaling protein (MAVS) is a pivotal adaptor in the antiviral
innate immune signaling pathway and plays a crucial role in the activation of antiviral …

The RNA-binding protein RIG-I is a key initiator of the antiviral innate immune response. The
signaling that mediates the antiviral response downstream of RIG-I is transduced through …

Mitochondria not only serve as a platform for innate immune signaling transduction but also
enhance immune responses by releasing mitochondrial DNA and RNA into the cytoplasm …

ABSTRACT TAX1BP1 is a selective macroautophagy/autophagy receptor that inhibits NFKB
and RIGI-like receptor (RLR) signaling to prevent excessive inflammation and maintain …

Chicken gout resulting from nephropathogenic infectious bronchitis virus (NIBV) has
become a serious kidney disease problem in chicken worldwide with alterations of the …

The RIG-I–like receptor (RLR) signaling pathway is pivotal for innate immunity against
invading viruses, and dysregulation of this molecular cascade has been linked to various …

Protein function is regulated by posttranslational modifications (PTMs), among which
reversible oxidation of cysteine residues has emerged as a key regulatory mechanism of …

Human infection with avian influenza A (H5N1) and (H7N9) viruses causes severe
respiratory diseases. PB1-F2 protein is a critical virulence factor that suppresses early type I …

Simple Summary Goats are important domestic animals that provide meat, milk, fur, and
other products for humans. The demand for these products has increased in recent years …