Transforming growth factor‐β (TGF‐β) superfamily signaling via their cognate receptors is
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …

Cystic fibrosis (CF) is the most common lethal, multisystemic genetic disorder in Caucasians.
Mutations in the gene encoding the cystic fibrosis transmembrane regulator (CFTR) protein …

Cystic fibrosis (CF)‐associated liver disease (CFLD) is a hepatobiliary complication of CF.
Current diagnostic modalities rely on nonspecific assessments, whereas liver biopsy is the …

Background & Aims Liver disease is the third leading cause of death in patients with cystic
fibrosis (CF), but features of patients with CF, severe liver disease, and portal hypertension …

Due to improved medical care, life expectancy in patients with cystic fibrosis (CF) has
veritably improved over the last decades. Importantly, cystic fibrosis related liver disease …

Results CF is due to mutations in the gene on chromosome 7 that encodes an amino acidic
polypeptide named CFTR (cystic fibrosis transmembrane regulator). The hepatic …

About 30% of patients with Cystic Fibrosis (CF) develop CF-associated liver disease (CFLD).
Recent studies have shown that transient elastography (TE), as a method to quantify liver …

Gastrointestinal complications of CF are likely to be seen with increasing frequency as
patients with CF lead longer lives. CF animal models and modern research techniques are …

Background. Liver disease associated with cystic fibrosis (CFLD) is the second cause of
mortality in these patients. The diagnosis is difficult because none of the available tests are …

Nonalcoholic steatohepatitis (NASH) is characterized by hepatic steatosis with inflammation
and fibrosis. Membrane endoglin (Eng) expression is shown to participate in fibrosis, and …