Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is
characterized by the concomitant occurrence of often severe thrombocytopenia …

Summary von Willebrand factor (VWF) is a key player in hemostasis, acting as a carrier for
factor VIII and capturing platelets at sites of vascular damage. To capture platelets, it must …

Thrombotic thrombocytopenic purpura (TTP) is a severe thrombotic microangiopathy. The
current pathophysiologic paradigm suggests that the ADAMTS13 deficiency leads to Ultra …

IgG4 autoimmune diseases (IgG4-AID) are an emerging group of autoimmune diseases that
are caused by pathogenic autoantibodies of the IgG4 subclass. It has only recently been …

Immune thrombotic thrombocytopenic purpura (iTTP) is an autoimmune disorder of which
the etiology is not fully understood. Autoantibodies targeting ADAMTS13 in iTTP patients …

Thrombotic microangiopathies are rare disorders characterized by the concomitant
occurrence of severe thrombocytopenia, microangiopathic hemolytic anemia, and a variable …

Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic
antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of …

Although outstanding progress has been made in understanding the pathophysiology of
thrombotic thrombocytopenic purpura (TTP), knowledge of the immunopathogenesis of the …

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare autoimmune
disorder caused by neutralizing anti-ADAMTS13 autoantibodies. In white individuals, HLA …