This review assesses the parallel literature on the role of gamma-aminobutyric acid (GABA)
in brain plasticity and GABA elements dysfunction related disorders. I review historical and …

SETD1A encodes a histone methyltransferase whose de novo mutations are identified in
schizophrenia (SCZ) patients and confer a large increase in disease risk. Here, we generate …

Adaptive behavior critically depends on the detection of behaviorally relevant stimuli. The
anterior insular cortex (aIC) has long been proposed as a key player in the representation …

Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are promising targets for
multiple psychiatric and neurodegenerative disorders. Understanding the subtype selectivity …

It has been proposed that the Glutamate (Glu) system is implicated in autism spectrum
disorders (ASD) via an imbalance between excitatory and inhibitory brain circuits, which …

Despite the higher prevalence of post-traumatic stress disorder (PTSD) in women, the
majority of preclinical research has been conducted utilizing male subjects. We have found …

Fragile X (FX) syndrome is one of the leading inherited causes of autism spectrum disorder
(ASD). A majority of FX and ASD patients exhibit sensory hypersensitivity, including auditory …

Chronic neuropathic pain caused by nerve damage is a most common clinical symptom,
often accompanied by anxiety-and depression-like symptoms. Current treatments are very …

Subtype 5 metabotropic glutamate receptors (mGlu5) are known to play an important role in
regulating cognitive, social and valence systems. However, it remains largely unknown at …

Background mGlu5 metabotropic glutamate receptors are considered as candidate drug
targets in the treatment of “monogenic” forms of autism spectrum disorders (ASD), such as …