New halogen-containing drugs approved by FDA in 2021: An overview on their syntheses and pharmaceutical use
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in
the year 2021) containing at least one halogen atom (covalently bound). The structures …
the year 2021) containing at least one halogen atom (covalently bound). The structures …
Pulmonary artery smooth muscle cell phenotypic switching: a key event in the early stage of pulmonary artery hypertension
B Ma, Y Cao, J Qin, Z Chen, G Hu, Q Li - Drug Discovery Today, 2023 - Elsevier
Highlights•PAH is a progressive pulmonary vascular disease characterized by excessive
pulmonary vasoconstriction and pulmonary vascular remodeling.•Although currently drugs …
pulmonary vasoconstriction and pulmonary vascular remodeling.•Although currently drugs …
Allosteric site identification, virtual screening and discovery of a sulfonamide Hsp110-STAT3 interaction inhibitor for the treatment of hypoxic pulmonary arterial …
C Zhao, Y Wu, M Li, W Tan, Y Hu, Y Wang… - European Journal of …, 2024 - Elsevier
Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular disorder marked by
vascular remodeling, which is linked to the malignant phenotypes of pulmonary vascular …
vascular remodeling, which is linked to the malignant phenotypes of pulmonary vascular …
The mechanism of the imbalance between proliferation and ferroptosis in pulmonary artery smooth muscle cells based on the activation of SLC7A11
P Hu, Y Xu, Y Jiang, J Huang, Y Liu, D Wang… - European Journal of …, 2022 - Elsevier
Pulmonary arterial hypertension (PAH) is a chronic, progressive pulmonary vascular
disease. Pulmonary vascular remodelling (PVR) is one of the main pathological features of …
disease. Pulmonary vascular remodelling (PVR) is one of the main pathological features of …
Updated perspective of EPAS1 and the role in pulmonary hypertension
N Wang, J Hua, Y Fu, J An, X Chen, C Wang… - Frontiers in Cell and …, 2023 - frontiersin.org
Pulmonary hypertension (PH) is a group of syndromes characterized by irreversible vascular
remodeling and persistent elevation of pulmonary vascular resistance and pressure, leading …
remodeling and persistent elevation of pulmonary vascular resistance and pressure, leading …
The small‐molecule formyl peptide receptor biased agonist, compound 17b, is a vasodilator and anti‐inflammatory in mouse precision‐cut lung slices
WR Studley, E Lamanna, KA Martin… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Pulmonary arterial hypertension (PAH), a rare fatal
disorder characterised by inflammation, vascular remodelling and vasoconstriction. Current …
disorder characterised by inflammation, vascular remodelling and vasoconstriction. Current …
Recent advances and future prospects of treatment of pulmonary hypertension
Pulmonary hypertension is one of the difficult situations to treat. Complex pathophysiology,
association of the multiple comorbidities make clinical scenario challenging. Recently it is …
association of the multiple comorbidities make clinical scenario challenging. Recently it is …
Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model
C Zhao, X Le, M Li, Y Hu, X Li, Z Chen, G Hu, L Hu… - Respiratory …, 2023 - Springer
Background Pulmonary arterial hypertension (PAH) is a progressive and devastating
disease characterized by pulmonary vascular remodeling which is associated with the …
disease characterized by pulmonary vascular remodeling which is associated with the …
Treatment of hypertension by using natural herbs and their mechanism of action
BH Aloufi, MA Atwan… - Journal of Biochemical …, 2022 - jbiochemtech.com
The medical term used for blood pressure is Hypertension (HTN). Hypertension is a
common problem faced by most people today. The leading danger for many diseases such …
common problem faced by most people today. The leading danger for many diseases such …
A novel pyridine-2-one AMPK inhibitor: discovery, mechanism, and in vivo evaluation in a hypoxic pulmonary arterial hypertension rat model
W Tan, Y Wang, M Li, C Zhao, Y Hu, R Gao… - European Journal of …, 2025 - Elsevier
AMP-activated protein kinase (AMPK), a heterotrimeric serine-threonine kinase, has been
identified as a promising target for regulating vascular remodeling in pulmonary arterial …
identified as a promising target for regulating vascular remodeling in pulmonary arterial …