Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

The cell cycle is an evolutionarily conserved process necessary for mammalian cell growth
and development. Because cell-cycle aberrations are a hallmark of cancer, this process has …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Purpose: The adoptive transfer of T cells modified to express a chimeric antigen receptor
(CAR) comprised of an extracellular single-chain antibody (scFV) fragment specific for a …

We have extensively characterized the DNA methylomes of 139 patients with chronic
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …

Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

Chronic lymphocytic leukemia (CLL), an incurable malignancy of mature B lymphocytes,
involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes …

B-cell receptor (BCR) signaling is a critical pathway in the pathogenesis of several B-cell
malignancies, including chronic lymphocytic leukemia (CLL), and can be targeted by …

Background Most patients with chronic lymphocytic leukaemia or small lymphocytic
lymphoma relapse after initial therapy. Bendamustine plus rituximab is often used in the …

Since its initial identification in 1992 as a possible class 1 cell-surface receptor without a
known parent ligand, receptor tyrosine kinase–like orphan receptor 1 (ROR1) has stimulated …