The heart undergoes a dynamic maturation process following birth, in response to a wide
range of stimuli, including both physiological and pathological cues. This process entails …

One of the many unresolved obstacles in the field of cardiovascular research is an
uncompromising in vitro cardiac model. While primary cell sources from animal models offer …

Cardiovascular diseases are the leading cause of global mortality and reduced quality of
life. Human-induced pluripotent stem cells-derived cardiomyocytes (hiPSC-CMs) provide a …

Anthracyclines such as doxorubicin (Dox) are effective chemotherapeutic agents, however
their use is hampered by subsequent cardiotoxicity risk. Our understanding of cardiomyocyte …

Trajectory inference (TI) or pseudotime analysis has dramatically extended the analytical
framework of single-cell RNA-seq data, allowing regulatory genes contributing to cell …

The inability to quantify cardiomyocyte (CM) maturation remains a significant barrier to
evaluating the effects of ongoing efforts to produce adult-like CMs from pluripotent stem cells …

Various cell types can be derived from stem cells. However, these cells are immature and do
not match their adult counterparts in functional capabilities, limiting their use in disease …

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reliance Supplemental material placed on this supplemental material which has been …