Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

With increase in life expectancy, the number of persons suffering from common age-related
brain diseases, including neurodegenerative (eg, dementia) and cerebrovascular (eg …

Importance Identifing potential screening tests for future cognitive decline is a priority for
developing treatments for and the prevention of dementia. Objective To examine the …

The last decade has seen a substantial increase in research focused on the identification,
development, and validation of diagnostic and prognostic retinal biomarkers for Alzheimer's …

Introduction Retinal nerve fiber layer (RNFL) thinning, assessed by optical coherence
tomography (OCT), has recently been reported in various dementias. Methods We …

Background Alzheimer's Disease (AD) can cause degeneration in the retina and optic nerve
either directly, as a result of amyloid beta deposits, or secondarily, as a result of the …

Neurodegenerative diseases present a current challenge for accurate diagnosis and for
providing precise prognostic information. Developing imaging biomarkers for multiple …

Background: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are leading
causes of cognitive decline. Optical coherence tomography (OCT) allows the measurement …

Introduction We conducted a 27-month longitudinal study of mid-life adults with preclinical
Alzheimer's disease (AD), using spectral domain optical coherence tomography to compare …