Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …

Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets.
Recent discoveries of essential lipolytic enzymes and characterization of numerous …

Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …

1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Fatty acids (FAs) are essential components of all lipid classes and pivotal substrates for
energy production in all vertebrates. Additionally, they act directly or indirectly as signaling …

Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme for triacylglycerol (TAG)
hydrolysis in adipocytes. The precise mechanisms whereby ATGL is regulated remain …

Triacylglycerol (TAG) is the primary unit of energy storage in eukaryotic cells. TAG comprises
more than 90% of the content of white adipocytes, and TAG synthesis is essential in …