A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry
Benzothiazole (BTA) and its derivatives are the most important heterocyclic compounds,
which are common and integral feature of a variety of natural products and pharmaceutical …
which are common and integral feature of a variety of natural products and pharmaceutical …
Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?
V Alterio, A Di Fiore, K D'Ambrosio, CT Supuran… - Chemical …, 2012 - ACS Publications
Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …
throughout most living organisms and encoded by five evolutionarily unrelated gene …
Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors
CT Supuran - Expert opinion on investigational drugs, 2018 - Taylor & Francis
Introduction: Hypoxic tumors overexpress two carbonic anhydrases (CA, EC 4.2. 1.1), CA IX
and XII, involved in complex processes connected to tumorigenesis (pH regulation …
and XII, involved in complex processes connected to tumorigenesis (pH regulation …
Comprehensive review in current developments of benzimidazole‐based medicinal chemistry
The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …
Carbonic anhydrases: role in pH control and cancer
The pH of the tumor microenvironment drives the metastatic phenotype and
chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH …
chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH …
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein− ligand binding
VM Krishnamurthy, GK Kaufman, AR Urbach… - Chemical …, 2008 - ACS Publications
Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …
Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas
CT Supuran - Expert opinion on therapeutic patents, 2018 - Taylor & Francis
The metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) is ubiquitously expressed in
organisms all over the phylogenetic tree, with seven genetically distinct families known to …
organisms all over the phylogenetic tree, with seven genetically distinct families known to …
Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes
Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have
appeared as a promising approach for pharmacological intervention in a variety of disorders …
appeared as a promising approach for pharmacological intervention in a variety of disorders …
Derivatives of benzimidazole pharmacophore: Synthesis, anticonvulsant, antidiabetic and DNA cleavage studies
RV Shingalapur, KM Hosamani, RS Keri… - European journal of …, 2010 - Elsevier
In seeking broad spectrum pharmacological activities of benzimidazole derivatives, a group
of 4-thiazolidinones 5 (a–j) and 1, 3, 4-oxadiazoles 6 (a–j) containing 2-mercapto …
of 4-thiazolidinones 5 (a–j) and 1, 3, 4-oxadiazoles 6 (a–j) containing 2-mercapto …