The availability of the human genome sequence has revolutionized the strategy of
employing nucleic acids with sequences complementary to specific target genes to improve …

In the past 4 years, RNA interference (RNAi) has become widely used as an experimental
tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an …

This study aimed to investigate the relationships between structures of gene carrier
molecules and their activities for gene delivery into cells. We compared 2 types of poly (l …

Living cells are remarkably complex. To unravel this complexity, living-cell assays have
been developed that allow delivery of experimental stimuli and measurement of the resulting …

In order to understand the behavior of individual cells, single cell analyses have attracted
attention since most cell-based assays provide data with values averaged across a large …

Gene silencing by siRNA (short interfering RNA) is a still developing field in biology and has
evolved as a novel post-transcriptional gene silencing strategy with therapeutic potential …

Here we describe lentivirus-infected cell microarrays for the high-throughput screening of
gene function in mammalian cells. To create these arrays, we cultured mammalian cells on …

MicroRNAs (miRNAs) are highly conserved, tiny (∼ 22 nucleotides) non-coding RNAs that
have emerged as potent regulators of mRNA translation. miRNAs exhibit fine-tuning of the …

Genomic studies provide scientists with methods to quickly analyse genes and their
products en masse. The first high-throughput techniques to be developed were sequencing …

Optical fibers have been used to develop sensors based on nucleic acids and cells. Sensors
employing DNA probes have been developed for various genomics applications and …