Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …

Although T cell help for B cells was described several decades ago, it was the identification
of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of …

Tissue injury and inflammatory response trigger the development of fibrosis in various
diseases. It has been recognized that both innate and adaptive immune cells are important …

Antigen-driven selection has been implicated in the pathogenesis of monoclonal
gammopathies. Patients with Gaucher's disease have an increased risk of monoclonal …

All cases of multiple myeloma (MM) are preceded by precursor states termed monoclonal
gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). Genetic …

Gaucher disease (GD) involves the accumulation of glucosylceramide (GL1) and its
deacylated lysolipid, glucosylsphingosine (lyso‐GL1) which is implicated in mediating …

The challenges in the diagnosis, prognosis, and monitoring of Gaucher disease (GD), an
autosomal recessive inborn error of glycosphingolipid metabolism, can negatively impact …

Over the past decades, tremendous progress has been made in the field of Gaucher
disease, the inherited deficiency of the lysosomal enzyme glucocerebrosidase. Many of the …

Two mechanisms are involved in the immune escape of cancer cells: the immunoediting of
tumor cells and the suppression of the immune system. Both processes have been revealed …

Natural killer T (NKT) cells are innate-like lymphocytes that generally recognize lipid
antigens and are enriched in microvascular compartments of the liver. NKT cells can be …