As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

A healthy proteome is essential for cell survival. Protein misfolding is linked to a rapidly
expanding list of human diseases, ranging from neurodegenerative diseases to aging and …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

The asymmetric cell division of stem cells, which produces one stem cell and one
differentiating cell, has emerged as a mechanism to balance stem cell self-renewal and …

Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by
prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed …

There exists a phenomenon in aging research whereby early life stress can have positive
impacts on longevity. The mechanisms underlying these observations suggest a robust, long …

Protein misfolding is a major driver of ageing‐associated frailty and disease pathology.
Although all cells possess multiple, well‐characterised protein quality control systems to …

The accumulation of damaged and aggregated proteins is a hallmark of aging and
increased proteotoxic stress. To limit the toxicity of damaged and aggregated proteins and to …

Hsp104 is a hexameric AAA+ ATPase and protein disaggregase found in yeast, which
couples ATP hydrolysis to the dissolution of diverse polypeptides trapped in toxic …

Small heat shock proteins (sHsps) exhibit an ATP-independent chaperone activity to prevent
the aggregation of misfolded proteins in vitro. The seemingly conflicting presence of sHsps …