Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Highlights•Explores the mechanism of glycation and AGE production.•Describes the
aberrantly activated pathways through AGE-RAGE interaction.•Emphasizes the important of …

Oxidative stress and protein modifications are frequently observed in numerous disease
states. Glucose constitutes a vital nutrient necessary to cellular oxygen metabolism …

Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …

Heat shock proteins (HSP) HSP27 and HSP70 are expressed in response to a wide variety
of physiological and environmental insults including anticancer chemotherapy, thus allowing …

Glycation of proteins forms fructosamines and advanced glycation endproducts. Glycation
adducts may be risk markers and risk factors of disease development. We measured the …

Recent progress in the development of molecular cancer therapeutics has revealed new
types of antitumor drugs, such as Herceptin, Gleevec, and Iressa, as potent therapeutics for …

Heat-shock proteins are produced in response to different types of stress conditions making
cells resistant to stress-induced cell damage. Under normal conditions, heat-shock proteins …

Heat shock proteins (Hsp) form the most ancient defense system in all living organisms on
earth. These proteins act as molecular chaperones by helping in the refolding of misfolded …

Diabetes is one of the most frequent diseases throughout the world and its incidence is
predicted to exponentially progress in the future. This metabolic disorder is associated with …