Relapses (episodic exacerbations of neurological signs or symptoms) are a defining feature
of relapsing-remitting multiple sclerosis (MS), the most prevalent MS phenotype. While their …

Multiple sclerosis is a debilitating disorder resulting from scattered lesions in the central
nervous system. Because of the high variability of the lesion patterns between patients, it is …

The radiologically isolated syndrome (RIS) was defined in 2009 as the presence of
asymptomatic, incidentally identified demyelinating-appearing white matter lesions in the …

Magnetic resonance imaging (MRI) has developed into the most important tool for the
diagnosis and monitoring of multiple sclerosis (MS). Its high sensitivity for the evaluation of …

Spontaneous fluctuations of neuronal activity in large-scale distributed networks are a
hallmark of the resting brain. In relapsing-remitting multiple sclerosis (RRMS) several fMRI …

Magnetic resonance imaging (MRI) of the brain and spinal cord plays a crucial role in the
diagnosis and monitoring of multiple sclerosis (MS). There is conclusive evidence that brain …

We aim to determine if machine learning techniques, such as support vector machines
(SVMs), can predict the occurrence of a second clinical attack, which leads to the diagnosis …

Multiple sclerosis (MS) is a neurological disease with an early course that is characterised
by attacks of clinical worsening, separated by variable periods of remission. The ability to …

Background As disease progression remains poorly understood in multiple sclerosis (MS),
we aim to investigate the sequence in which different disease milestones occur using a …

Objective Escalation (ES) and early high-efficacy (EHE) therapies have been the main
treatment strategies adopted in multiple sclerosis (MS) in recent years. The aim of this study …