Inflammation promotes the development of heart failure (HF). The inflammasome is a
multimeric protein complex that plays an essential role in the innate immune response by …

Abstract Absent in melanoma 2 (AIM2) is a cytoplasmic sensor that recognises the double-
strand DNA. AIM2 inflammasome is a protein platform in the cell that initiates innate immune …

The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …

Cardiovascular diseases are known as the leading cause of morbidity and mortality
worldwide. As an innate immune signaling complex, inflammasomes can be activated by …

According to the latest Global Burden of Disease Study, cardiovascular disease (CVD) is the
leading cause of death, and ischemic heart disease and stroke are the cause of death in …

Background Melanoma, as one of the most aggressive and malignant cancers, ranks first in
the lethality rate of skin cancers. Cuproptosis has been shown to paly a role in …

The pivotal role of inflammation in the pathophysiology of heart-failure (HF) development
and progression has long been recognized. High blood levels of pro-inflammatory and …

The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …

Abstract Rationale: Extracellular vesicles (EVs) from human explant-derived cells injected
directly into the atria wall muscle at the time of open chest surgery reduce atrial fibrosis …

目的: 通过检测心房颤动(房颤) 患者血清中NLR 家族含CARD 结构蛋白4 (NLRC4)
和半胱氨酸天冬氨酸特异蛋白酶1 (Caspase-1) 的表达水平变化, 探讨二者在房颤发展中的规律 …