Polyketide retrobiosynthesis, where the biosynthetic pathway of a given polyketide can be
reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and …

Modular polyketide synthases (PKSs) are a multidomain megasynthase class of biosynthetic
enzymes that have great promise for the development of new compounds, from new …

The chemical scaffolds of numerous therapeutics are polyketide natural products, many
formed by bacterial modular polyketide synthases (PKS). The large and flexible dimeric PKS …

Polyketide synthase (PKS) engineering is an attractive method to generate new molecules
such as commodity, fine and specialty chemicals. A significant challenge is re-engineering a …

Megasynthase enzymes such as type I modular polyketide synthases (PKSs) and
nonribosomal peptide synthetases (NRPSs) play a central role in microbial chemical warfare …

In the biosynthesis of the macrolactam antibiotic cremimycin, the 3-aminononanoic acid
starter unit is formed via a non-2-enoyl acyl carrier protein thioester intermediate, which is …

The field of combinatorial chemistry is highly interested in determining the structure of
polyketide synthases (PKS) to manipulate existing PKS systems into producing macrolide …

Les polycétides sont des métabolites spécialisés synthétisés par une grande variété
d'organismes incluant les bactéries, les champignons, les végétaux ou encore certains …

Nature has long provided valuable pharmaceuticals, with many effective antibiotics
originating from soil and plants. Yet, rising antibiotic resistance and repeated rediscovery of …

Polyketides are a natural chemical class of complex, frequently bioactive molecules, from
which several therapeutics have been derived. Large enzyme complexes, polyketide …