15 years of GWAS discovery: realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
Polygenic risk scores for cardiovascular disease: a scientific statement from the American Heart Association
Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …
Polygenic scores in biomedical research
Public health strategies aimed at disease prevention or early detection and intervention
have the potential to advance human health worldwide. However, their success depends on …
have the potential to advance human health worldwide. However, their success depends on …
Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …
factors and comprise common noncommunicable diseases, including allergies …
Molecular mechanisms of vascular health: insights from vascular aging and calcification
Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …
Genome-wide association studies of cardiovascular disease
R Walsh, SJ Jurgens, J Erdmann… - Physiological …, 2023 - journals.physiology.org
Genome-wide association studies (GWAS) aim to identify common genetic variants that are
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
associated with traits and diseases. Since 2005, more than 5,000 GWAS have been …
Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
L Ottensmann, R Tabassum, SE Ruotsalainen… - Nature …, 2023 - nature.com
The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …
lipid-associated variants and understand the link between lipid species and cardiometabolic …
Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization
ACF Lewis, EF Perez, AER Prince, HR Flaxman… - Genome Medicine, 2022 - Springer
Background Polygenic risk scores (PRS), which offer information about genomic risk for
common diseases, have been proposed for clinical implementation. The ways in which PRS …
common diseases, have been proposed for clinical implementation. The ways in which PRS …
Polygenic risk scores for the prediction of cardiometabolic disease
Cardiometabolic diseases contribute more to global morbidity and mortality than any other
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …
Advances and applications of polygenic scores for coronary artery disease
Polygenic scores quantify inherited risk by integrating information from many common sites
of DNA variation into a single number. Rapid increases in the scale of genetic association …
of DNA variation into a single number. Rapid increases in the scale of genetic association …