Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

In Situ Capture and Real-Time Enrichment of Marine Chemical Diversity

M Mauduit, M Derrien, M Grenier, S Greff… - ACS Central …, 2023 - ACS Publications
Analyzing the chemical composition of seawater to understand its influence on ecosystem
functions is a long-lasting challenge due to the inherent complexity and dynamic nature of …

A Structure-Guided Molecular Network Strategy for Global Untargeted Metabolomics Data Annotation

X Wang, C Li, Z Li, Y Qi, X Zhang, X Zhao… - Analytical …, 2023 - ACS Publications
Large-scale metabolite annotation is a bottleneck in untargeted metabolomics. Here, we
present a structure-guided molecular network strategy (SGMNS) for deep annotation of …

Advanced technologies targeting isolation and characterization of natural products

SH Dong, ZK Duan, M Bai, XX Huang… - TrAC Trends in Analytical …, 2024 - Elsevier
Natural products (NPs), are small molecules produced naturally by any organism. As they
may be isolated in small quantities, having interesting biological activities and lush chemical …

Combining Experimental with Computational Infrared and Mass Spectra for High-Throughput Nontargeted Chemical Structure Identification

E Karunaratne, DW Hill, K Dührkop… - Analytical …, 2023 - ACS Publications
The inability to identify the structures of most metabolites detected in environmental or
biological samples limits the utility of nontargeted metabolomics. The most widely used …

Coral larval settlement induction using tissue-associated and exuded coralline algae metabolites and the identification of putative chemical cues

ZA Quinlan, MJ Bennett, MGI Arts… - … of the Royal …, 2023 - royalsocietypublishing.org
Reef-building crustose coralline algae (CCA) are known to facilitate the settlement and
metamorphosis of scleractinian coral larvae. In recent decades, CCA coverage has fallen …

Two-Dimensional Liquid Chromatography Tandem Mass Spectrometry Untangles the Deep Metabolome of Marine Dissolved Organic Matter

S Papadopoulos Lambidis, T Schramm… - Environmental …, 2024 - ACS Publications
Dissolved organic matter (DOM) is an ultracomplex mixture that plays a central role in global
biogeochemical cycles. Despite its importance, DOM remains poorly understood at the …

Computational Methods Reveal a Series of Cyclic and Linear Lichenysins and Surfactins from the Vietnamese Marine Sediment-Derived Streptomyces Strain G222

A Castaldi, BN Truong, QT Vu, THM Le, A Marie… - Molecules, 2024 - mdpi.com
The Streptomyces strain G222, isolated from a Vietnamese marine sediment, was
confidently identified by 16 S rRNA gene sequencing. Its AcOEt crude extract was …

Molecular networking-based mass spectral identification of Brucea javanica (L.) Merr. metabolites and their selective binding affinities for dengue virus enzymes

NSAM Yousof, A Afzan, M Zainol, SIA Bakar… - Fitoterapia, 2024 - Elsevier
Brucea javanica, a valued traditional medicinal plant in Malaysia, known for its fever-treating
properties yet remains underexplored for its potential antiviral properties against dengue …

Ontogeny and organ‐specific steroidal glycoside diversity is associated with differential expression of steroidal glycoside pathway genes in two Solanum dulcamara …

RA Anaia, I Chiocchio, R Sontowski, B Swinkels… - Plant …, 2024 - Wiley Online Library
Solanaceous plants, such as Solanum dulcamara, produce steroidal glycosides (SGs). Leaf
SG profiles vary among S. dulcamara individuals, leading to distinct phytochemical …