Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

DNA methylation (DNAm) is one of the most reliable biomarkers of aging across mammalian
tissues. While the age-dependent global loss of DNAm has been well characterized, DNAm …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

Polycomb group proteins and the related histone modification H3K27me3 can maintain the
silencing of key developmental regulators and provide cellular memory. However, how such …

With age, skeletal muscle stem cells (MuSCs) activate out of quiescence more slowly and
with increased death, leading to defective muscle repair. To explore the molecular …

Both DNA methylation and histone modification are involved in establishing patterns of gene
repression during development. Certain forms of histone methylation cause local formation …

Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the
methylation of lysine 27 on histone H3 (H3K27me). This histone modification is a feature of …

While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic
alterations during tumorigenesis including aberrant DNA hypermethylation of tumor …

DNA methylation at proximal promoters facilitates lineage restriction by silencing cell type–
specific genes. However, euchromatic DNA methylation frequently occurs in regions outside …