Kinesins, mechanochemical enzymes that utilize the energy of ATP to translocate along or
destabilize microtubules, are essential for accurate completion of cell division. Recently …

Sequences and available structures were compared for all the widely distributed
representatives of the P-loop GTPases and GTPase-related proteins with the aim of …

New crystal structures of the kinesin motors differ from previously described motor-ADP
atomic models, showing striking changes both in the switch I region near the nucleotide …

We have identified a missense mutation in the motor domain of the neuronal kinesin heavy
chain gene KIF5A, in a family with hereditary spastic paraplegia. The mutation occurs in the …

Kinesin motors are specialized enzymes that use hydrolysis of ATP to generate force and
movement along their cellular tracks, the microtubules. Although numerous biochemical and …

In this work, we report on a study of the structure-function relationships for three families of
motor proteins, including kinesins, myosins, and F1-ATPases, by using a version of the …

The typical function of kinesins is to transport cargo along microtubules. Binding of ATP to
microtubule-attached motile kinesins leads to cargo displacement. To better understand the …

Crimella C, Baschirotto C, Arnoldi A, Tonelli A, Tenderini E, Airoldi G, Martinuzzi A, Trabacca
A, Losito L, Scarlato M, Benedetti S, Scarpini E, Spinicci G, Bresolin N, Bassi MT. Mutations …

Kinesin is an ATP-driven molecular motor protein that moves processively along
microtubules. Despite considerable research, the detailed mechanism of kinesin motion …

The matrix metalloproteinase (MMP) MT1-MMP plays pivotal roles in leukocyte physiology
such as monocyte diapedesis, dendritic cell migration, and T-cell homing. MT1-MMP is a …