The gate theory of pain, published by Ronald Melzack and Patrick Wall in Science in 1965,
was formulated to provide a mechanism for coding the nociceptive component of cutaneous …

Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

Six members of the mammalian transient receptor potential (TRP) ion channels respond to
varied temperature thresholds. The natural compounds capsaicin and menthol activate …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Background Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive
pathways in human peripheral and central nervous system and its receptors are also …

Tendon pain remains an enigma. Many clinical features are consistent with tissue disruption—
the pain is localised, persistent and specifically associated with tendon loading, whereas …

The abilities to sense environmental and internal temperatures are required for survival,
both for maintenance of homeostasis and for avoidance of tissue-damaging noxious …

The present review examines the experimental evidence supporting the existence of central
mechanisms able to modulate the synaptic effectiveness of sensory fibers ending in the …

While sensory fibres normally respond to a range of physical and chemical stimuli their
activity and metabolism are profoundly altered by a variety of mediators generated by tissue …