Over the past 4 years, nearly 100 exome sequencing studies have revealed the high
frequency of mutations in the genes encoding the subunits of ATP-dependent chromatin …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Recent genome-sequencing studies in human neurodevelopmental and psychiatric
disorders have uncovered mutations in many chromatin regulators. These human genetic …

The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …

Mammalian neural stem cells (NSCs) have the capacity to both self-renew and to generate
all the neuronal and glial cell-types of the adult nervous system. Global chromatin changes …

▪ Abstract It has been a long-standing challenge to decipher the principles that enable cells
to both organize their genomes into compact chromatin and ensure that the genetic …

The development of tissues and organs in embryos is controlled by an interplay of several
signaling pathways that cross-talk to provide positional information and induce cell fate …

Eukaryotic genomes are organized into condensed, heterogeneous chromatin fibers
throughout much of the cell cycle. Here we describe recent studies indicating that even …

The mammalian BAF complex regulates gene expression by modifying chromatin structure.
In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in …

Organisms are constantly challenged by stresses and privations and require adaptive
responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 …