Neuroimmunology of traumatic brain injury: time for a paradigm shift

YN Jassam, S Izzy, M Whalen, DB McGavern… - Neuron, 2017 - cell.com
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Cellular infiltration in traumatic brain injury

A Alam, EP Thelin, T Tajsic, DZ Khan, A Khellaf… - Journal of …, 2020 - Springer
Traumatic brain injury leads to cellular damage which in turn results in the rapid release of
damage-associated molecular patterns (DAMPs) that prompt resident cells to release …

Animal models of traumatic brain injury

Y Xiong, A Mahmood, M Chopp - Nature Reviews Neuroscience, 2013 - nature.com
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life
and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling …

Neuroinflammation and blood–brain barrier disruption following traumatic brain injury: pathophysiology and potential therapeutic targets

S Sulhan, KA Lyon, LA Shapiro… - Journal of neuroscience …, 2020 - Wiley Online Library
Abstract Traumatic Brain Injury (TBI) is the most frequent cause of death and disability in
young adults and children in the developed world, occurring in over 1.7 million persons and …

Blood–brain barrier pathophysiology in traumatic brain injury

A Chodobski, BJ Zink… - Translational stroke …, 2011 - Springer
The blood–brain barrier (BBB) is formed by tightly connected cerebrovascular endothelial
cells, but its normal function also depends on paracrine interactions between the brain …

Cerebral vascular injury in traumatic brain injury

K Kenney, F Amyot, M Haber, A Pronger… - Experimental …, 2016 - Elsevier
Traumatic cerebral vascular injury (TCVI) is a very frequent, if not universal, feature after
traumatic brain injury (TBI). It is likely responsible, at least in part, for functional deficits and …

Traumatic brain injury pathophysiology and treatments: early, intermediate, and late phases post-injury

H Algattas, JH Huang - International journal of molecular sciences, 2013 - mdpi.com
Traumatic Brain Injury (TBI) affects a large proportion and extensive array of individuals in
the population. While precise pathological mechanisms are lacking, the growing base of …

Traumatic brain injury: an overview of pathobiology with emphasis on military populations

I Cernak, LJ Noble-Haeusslein - Journal of Cerebral Blood …, 2010 - journals.sagepub.com
This review considers the pathobiology of non-impact blast-induced neurotrauma (BINT).
The pathobiology of traumatic brain injury (TBI) has been historically studied in experimental …

Molecular and cellular basis of epileptogenesis in symptomatic epilepsy

A Pitkänen, K Lukasiuk - Epilepsy & behavior, 2009 - Elsevier
Epileptogenesis refers to a process in which an initial brain-damaging insult triggers a
cascade of molecular and cellular changes that eventually lead to the occurrence of …

Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?

N Marklund, L Hillered - British journal of pharmacology, 2011 - Wiley Online Library
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults.
Survivors of TBI frequently suffer from long‐term personality changes and deficits in …