[HTML][HTML] Antifungal drug-resistance mechanisms in Candida biofilms

J Kaur, CJ Nobile - Current opinion in microbiology, 2023 - Elsevier
Highlights•Few classes of antifungal drugs currently exist to treat fungal infections.•Infections
caused by Candida biofilms can be resistant to known antifungal drugs.•Growth in the …

Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis

C Rodríguez-Cerdeira, E Martínez-Herrera… - Frontiers in …, 2020 - frontiersin.org
The ability of Candida spp. to form biofilms is crucial for its pathogenicity, and thus, it should
be considered an important virulence factor in vulvovaginal candidiasis (VVC) and recurrent …

Fungal quorum-sensing molecules and inhibitors with potential antifungal activity: a review

A Mehmood, G Liu, X Wang, G Meng, C Wang, Y Liu - Molecules, 2019 - mdpi.com
The theory of persisting independent and isolated regarding microorganisms is no longer
accepted. To survive and reproduce they have developed several communication platforms …

Farnesol and Tyrosol: Secondary Metabolites with a Crucial quorum-sensing Role in Candida Biofilm Development

CF Rodrigues, L Černáková - Genes, 2020 - mdpi.com
When living in biological and interactive communities, microorganisms use quorum-sensing
mechanisms for their communication. According to cell density, bacteria and fungi can …

Mixed biofilms of pathogenic Candida-bacteria: regulation mechanisms and treatment strategies

F Khan, NI Bamunuarachchi, DTN Pham… - Critical reviews in …, 2021 - Taylor & Francis
Mixed-species biofilm is one of the most frequently recorded clinical problems. Mixed
biofilms develop as a result of interactions between microorganisms of a single or multiple …

Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms

R Kovács, L Majoros - Journal of Fungi, 2020 - mdpi.com
The number of effective therapeutic strategies against biofilms is limited; development of
novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum …

Effects of tyrosol and farnesol on Candida albicans biofilm

S Sebaa, Z Boucherit-Otmani… - Molecular medicine …, 2019 - spandidos-publications.com
The present in vitro study examined the effects of the quorum-sensing molecules farnesol
and tyrosol on the development of Candida albicans biofilm in order to elucidate their role as …

In vitro and in vivo Effect of Exogenous Farnesol Exposure Against Candida auris

F Nagy, E Vitális, Á Jakab, AM Borman… - Frontiers in …, 2020 - frontiersin.org
The spreading of multidrug-resistant Candida auris is considered as an emerging global
health threat. The number of effective therapeutic regimens is strongly limited; therefore …

Plausible Mechanistic Insights in Biofilm Eradication Potential against Candida spp. Using In Situ-Synthesized Tyrosol-Functionalized Chitosan Gold Nanoparticles …

TC Yadav, P Gupta, S Saini, S Mohiyuddin, V Pruthi… - ACS …, 2022 - ACS Publications
In the present study, tyrosol-functionalized chitosan gold nanoparticles (Chi-TY-AuNPs)
were prepared as an alternative treatment strategy to combat fungal infections. Various …

Impact of the host microbiota on fungal infections: New possibilities for intervention?

EWL Chow, LM Pang, Y Wang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Many human fungal pathogens are opportunistic. They are primarily benign residents of the
human body and only become infectious when the host's immunity and microbiome are …