Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second
messenger cyclic adenosine 3′, 5′ monophosphate (cAMP). sAC is distinct from the more …

In biological systems, carbon dioxide exists in equilibrium with bicarbonate and protons. The
individual components of this equilibrium (ie, CO 2, HCO 3−, and H+), which must be sensed …

Astrocytes are proposed to participate in brain energy metabolism by supplying substrates to
neurons from their glycogen stores and from glycolysis. However, the molecules involved in …

The vasopressin type 2 receptor (V2R) is a critical G protein-coupled receptor (GPCR) for
vertebrate physiology, including the balance of water and sodium ions. It is unclear how its …

Modulation of environmental pH is critical for the function of many biological systems.
However, the molecular identity of the pH sensor and its interaction with downstream effector …

The circadian clock protein period 1 (Per1) contributes to the regulation of expression of the
α subunit of the renal epithelial sodium channel at the basal level and in response to the …

Acid-base homeostasis is essential for life. The macromolecules upon which living
organisms depend are sensitive to pH changes, and physiological systems use the …

Cyclic AMP (cAMP), the prototypical second messenger, has been implicated in a wide
variety of (often opposing) physiological processes. It simultaneously mediates multiple …

cAMP is a critical second messenger mediating activity-dependent neuronal survival and
neurite growth. We investigated the expression and function of the soluble adenylyl cyclase …

Abstract The epithelial Na+ channel, ENaC, and the Cl−/HCO 3− exchanger, pendrin,
mediate NaCl absorption within the cortical collecting duct and the connecting tubule …