[HTML][HTML] Oral exposure to polyethylene microplastics induces inflammatory and metabolic changes and promotes fibrosis in mouse liver.

M Djouina, C Waxin, L Dubuquoy, D Launay… - Ecotoxicology and …, 2023 - Elsevier
Accumulating evidence shows widespread contamination of water sources and food with
microplastics. Although the liver is one of the main sites of bioaccumulation within the …

Activated hepatic nuclear factor-κB in experimental colitis regulates CYP2A5 and metronidazole disposition

L Ma, W Zeng, Z Tan, R Wang, Y Yang… - Molecular …, 2022 - ACS Publications
Systemic exposure of metronidazole is increased in patients with inflammatory bowel
diseases (IBDs), while the underlying mechanism remains unknown. Here, we aim to …

[HTML][HTML] Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC

A Kroh, J Walter, A Fragoulis, D Möckel, T Lammers… - Neoplasia, 2023 - Elsevier
Obesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH
became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of …

Diferencias entre la microbiota intestinal de hombres y mujeres y su relación con la prevalencia de desarrollo de enfermedades metabólicas

JA Santos Marcos - 2022 - helvia.uco.es
La creciente incidencia de las enfermedades metabólicas en la población mundial,
particularmente de la obesidad, el síndrome metabólico (SM), y la diabetes de tipo 2 (DT2) …

Impact toxicologique de contaminants alimentaires au niveau intestinal et hépatique

M Djouina - 2023 - theses.hal.science
Cette thèse examine les effets toxicologiques de contaminants alimentaires au niveau
intestinal et hépatique sur des modèles murins. Dans le premier chapitre, une revue de la …

Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage

T Kawamura, M Ichikawa, J Hatogai… - … & Drug Disposition, 2022 - Wiley Online Library
In the adult liver, drug‐metabolizing enzymes such as cytochrome P450 (CYP) efficiently
metabolize drugs by forming an expression pattern called “zonation” structure around the …