Sex hormones (SH) are essential regulators of the central nervous system. The decline in
SH levels along with ageing may contribute to compromised neuroprotection and set the …

Accumulation of amyloid-beta (Aβ) in the brain is thought to derive from the impairment of Aβ
clearance mechanisms rather than from its overproduction, which consequently contributes …

Premenstrual dysphoric disorder (PMDD) affects over 5% of women, with symptoms similar
to anxiety and major depression, and is associated with differential sensitivity to circulating …

The female sex hormone estradiol (E2, 17β-estradiol) has important functions in the
developing brain. In addition to regulating sexual differentiation of the brain, E2 participates …

Administration of 17β-estradiol (E 2) has beneficial effects on cognitive function in peri-but
not post-menopausal women, yet the molecular mechanisms underlying age-related …

The rapid decline of circulating 17β-estradiol (E2) at menopause leads to negative
neurological consequences, although hormone therapy paradoxically has both harmful and …

Loss of circulating 17β-estradiol (E2) that occurs during menopause can have detrimental
effects on cognitive function. The efficacy of hormone replacement therapy declines as …

Alternative RNA splicing results in the translation of diverse protein products arising from a
common nucleotide sequence. These alternative protein products are often functional and …

Nuclear steroid hormone receptors are ubiquitously expressed transcription factors whose
activity can be altered by post‐translational modifications, such as phosphorylation. The …

A major aging hallmark is the accumulation of cellular senescence burden. Over time
senescent cells contribute to tissue deterioration through chronic inflammation and fibrosis …