After the developing embryo has formed a primary vascular plexus by a process termed
vasculogenesis, further blood vessels are generated by both sprouting and non-sprouting …

Adaptive phenotypic plasticity provides a mechanism of developmental rescue in novel and
rapidly changing environments. Understanding the underlying mechanism of plasticity is …

"... but our knowledge is so weak that no philosopher will ever be able to completely explore
the nature of even a fly..."* Thomas Aquinas" In Symbolum Apostolorum" 079 RSV p/96 This …

The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …

A fundamental goal of genetics and functional genomics is to identify and mutate every gene
in model organisms such as Drosophila melanogaster. The Berkeley Drosophila Genome …

Serum response factor (SRF) is a widely expressed transcription factor involved in
orchestrating disparate programs of gene expression linked to muscle differentiation and …

Antagonists of several growth factor signaling pathways play important roles in
developmental patterning by limiting the range of the cognate inducer. Here, we describe an …

Serum response factor (SRF) is a highly conserved and widely expressed, single copy
transcription factor that theoretically binds up to 1,216 permutations of a 10-base pair cis …

Kinases belonging to the mitogen-activated protein kinase (MAPK) family are used
throughout evolution to control the cellular responses to external signals such as growth …

The association of transcriptional coactivators with sequence-specific DNA-binding proteins
provides versatility and specificity to gene regulation and expands the regulatory potential of …