Ion channels and channelopathies in glomeruli

A Staruschenko, R Ma, O Palygin… - Physiological …, 2023 - journals.physiology.org
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Physiological mechanisms of dietary salt sensing in the brain, kidney, and gastrointestinal tract

SD Stocker, BJ Kinsman, WB Farquhar, G Gyarmati… - …, 2024 - Am Heart Assoc
Excess dietary salt (NaCl) intake is strongly correlated with cardiovascular disease and is a
major contributing factor to the pathogenesis of hypertension. NaCl-sensitive hypertension is …

Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney

G Gyarmati, UN Shroff, A Riquier-Brison… - The Journal of …, 2024 - Am Soc Clin Investig
Tissue regeneration is limited in several organs, including the kidney, contributing to the
high prevalence of kidney disease globally. However, evolutionary and physiological …

Reduction in pappalysin-2 levels and lower IGF-I bioavailability in female adolescents with anorexia Nervosa

V Barrios, Á Martín-Rivada… - The Journal of …, 2024 - academic.oup.com
Context Anorexia nervosa (AN) can cause severe undernutrition associated with alterations
in the IGF axis. Pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC-1, STC-2) …

Intravital multiphoton microscopy as a tool for studying renal physiology, pathophysiology and therapeutics

BA Molitoris, RM Sandoval, MC Wagner - Frontiers in Physiology, 2022 - frontiersin.org
Intravital multiphoton microscopy has empowered investigators to study dynamic cell and
subcellular processes in vivo within normal and disease organs. Advances in hardware …

ZO‐1 expression in normal human macula densa: Immunohistochemical and immunofluorescence investigations

G Tossetta, S Fantone, M Senzacqua… - Journal of …, 2023 - Wiley Online Library
The macula densa (MD) is an anatomical structure having a plaque shape, placed in the
distal end of thick ascending limb of each nephron and belonging to juxtaglomerular …

See the power in kidney cells with ATP biosensor

J Peti-Peterdi, G Gyarmati - Kidney International, 2024 - Elsevier
Yamamoto et al. developed an exciting technical advance to examine intracellular
adenosine triphosphate levels with single-cell resolution in intact living kidney tissue …

Using 2-photon microscopy to quantify the effects of chronic unilateral ureteral obstruction on glomerular processes

C Mark, RM Sandoval, SB Campos-Bilderback… - JoVE (Journal of …, 2022 - jove.com
Applying novel microscopy methods to suitable animal disease models to explore the
dynamic physiology of the kidney remains a challenge. Rats with surface glomeruli provide …

Physiological activation of the nephron central command drives endogenous kidney tissue regeneration

G Gyarmati, UN Shroff, A Riquier-Brison, D Desposito… - bioRxiv, 2021 - biorxiv.org
Tissue regeneration is limited in several organs including the kidney, contributing to the high
prevalence of kidney disease globally. However, evolutionary and physiological adaptive …

Neuron-like function of the nephron central command

G Gyarmati, UN Shroff, A Riquier-Brison, SD Stocker… - Biorxiv, 2021 - biorxiv.org
Interoceptive neurons that sense and regulate our internal milieu have been identified in
several organs except in the kidney cortex despite its major importance in maintaining body …