Emerging roles of astrocytes as immune effectors in the central nervous system

TM Fisher, SA Liddelow - Trends in Immunology, 2024 - cell.com
The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded
as a functionally diverse mediator of homeostasis. During development and throughout …

[HTML][HTML] Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of alzheimer's disease

P Saha, SS Sisodia - Neurotherapeutics, 2024 - Elsevier
Alzheimer's disease (AD) presents distinct pathophysiological features influenced by
biological sex, with women disproportionately affected due to sex-specific genetic …

[HTML][HTML] Sex differences in astrocyte activity

E Gozlan, Y Lewit-Cohen, D Frenkel - Cells, 2024 - mdpi.com
Astrocytes are essential for maintaining brain homeostasis. Alterations in their activity have
been associated with various brain pathologies. Sex differences were reported to affect …

SIRT6 modulates lesion microenvironment in LPC induced demyelination by targeting astrocytic CHI3L1

J Du, Y Yin, D Wu, C Diao, T Zhao, F Peng, N Li… - Journal of …, 2024 - Springer
Demyelination occurs widely in the central nervous system (CNS) neurodegenerative
diseases, especially the multiple sclerosis (MS), which with a complex and inflammatory …

Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress

LM Holt, TM Gyles, EM Parise, AM Minier-Toribio… - Biological …, 2024 - Elsevier
Background Increasing evidence implicates astrocytes in stress and depression in both
rodent models and human major depressive disorder. Despite this, little is known about the …

Nucleus accumbens astrocytes bidirectionally modulate social behavior

JW VanRyzin, KJ Reissner - bioRxiv, 2024 - biorxiv.org
Social behaviors are critical for survival and fitness of a species, and maladaptive social
behaviors are frequently associated with neurodevelopmental and psychiatric disorders. As …