Recent synthetic strategies for the functionalization of fused bicyclic heteroaromatics using organo-Li,-Mg and-Zn reagents
V Dhayalan, VS Dodke, MP Kumar… - Chemical Society …, 2024 - pubs.rsc.org
This review highlights the use of functionalized organo-Li,-Mg and-Zn reagents for the
construction and selective functionalization of 5-and 6-membered fused bicyclic …
construction and selective functionalization of 5-and 6-membered fused bicyclic …
Exploring the Potential Therapeutic Role of Benzofuran Derivatives in Cancer Treatment
Benzofuran serves as the primary active pharmaceutical ingredient (API) in a plethora of
both naturally occurring and synthetic drugs known for their potent biological activities. The …
both naturally occurring and synthetic drugs known for their potent biological activities. The …
BTEAC catalyzed ultrasonic-assisted synthesis of bromobenzofuran-oxadiazoles: Unravelling anti-HepG-2 cancer therapeutic potential through in vitro and in silico …
In this work, BTEAC (benzyl triethylammonium chloride) was employed as a phase transfer
catalyst in an improved synthesis (up to 88% yield) of S-alkylated bromobenzofuran …
catalyst in an improved synthesis (up to 88% yield) of S-alkylated bromobenzofuran …
Novel benzochromenes: design, synthesis, cytotoxicity, molecular docking and mechanistic investigations
FG Abdulrahman, HS Abulkhair, RA Zidan… - Future Medicinal …, 2024 - Taylor & Francis
Aim: A novel series of fused benzochromenes with expected cytotoxicity and HIF-1α
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …
Discovery of some heterocyclic molecules as bone morphogenetic protein 2 (BMP-2)-inducible kinase inhibitors: virtual screening, ADME properties, and molecular …
Bone morphogenetic proteins (BMPs) are growth factors that have a vital role in the
production of bone, cartilage, ligaments, and tendons. Tumors' upregulation of bone …
production of bone, cartilage, ligaments, and tendons. Tumors' upregulation of bone …
Anticancer efficacy of biosynthesized silver nanoparticles loaded with recombinant truncated parasporin-2 protein
M Srisaisap, P Boonserm - Scientific Reports, 2024 - nature.com
Bacterial toxins have received a great deal of attention in the development of cancer
treatments. Parasporin-2 (PS2Aa1 or Mpp46Aa1) is a Bacillus thuringiensis parasporal …
treatments. Parasporin-2 (PS2Aa1 or Mpp46Aa1) is a Bacillus thuringiensis parasporal …
Exploring theophylline-1,2,4-triazole tethered N-phenylacetamide derivatives as antimicrobial agents: unraveling mechanisms via structure-activity relationship, in vitro …
S Saeed, I Shahzadi, AF Zahoor, AA Al-Mutairi… - Frontiers in …, 2024 - frontiersin.org
Theophylline, a nitrogen-containing heterocycle, serves as a promising focal point for
medicinal researchers aiming to create derivatives with diverse pharmacological …
medicinal researchers aiming to create derivatives with diverse pharmacological …
Potential MRSA inhibitory activity of some new benzofuran-pyrazolo[1,5-a]pyrimidine hybrids attached to arene units via methylene or azo linkage
MRSA, a resistant bacteria causing severe infections, is targeted by researchers developing
new anti-resistance compounds. The study aimed to investigate the MRSA inhibitory activity …
new anti-resistance compounds. The study aimed to investigate the MRSA inhibitory activity …
Scalable diastereoselective electrosynthesis of spiro [benzofuran-2, 2′-furan]-3-ones
I Yavari, S Shaabanzadeh… - The Journal of Organic …, 2023 - ACS Publications
Spirobenzofuran scaffolds, because of their three-dimensional structure, are incorporated
into several valuable natural products and drug candidate molecules. Herein, with the …
into several valuable natural products and drug candidate molecules. Herein, with the …
Synthesis of novel bis-thiazoles, bis-thienopyridines, and bis-triazolothiadiazines linked to diphenyl ether core as novel hybrid molecules
AHM Elwahy, ARS Ginidi, MR Shaaban… - Synthetic …, 2023 - Taylor & Francis
The reaction of the appropriate α-haloketones or α-keto-hydrazonoyl chlorides with the
corresponding bis (hydrazinecarbothioamide) in EtOH at reflux in the presence of a few …
corresponding bis (hydrazinecarbothioamide) in EtOH at reflux in the presence of a few …