HIV infection
More than 75 million people worldwide have been infected with human immunodeficiency
virus (HIV), and there are now approximately 37 million individuals living with the infection …
virus (HIV), and there are now approximately 37 million individuals living with the infection …
HIV and HLA class I: an evolving relationship
PJR Goulder, BD Walker - Immunity, 2012 - cell.com
Successful vaccine development for infectious diseases has largely been achieved in
settings where natural immunity to the pathogen results in clearance in at least some …
settings where natural immunity to the pathogen results in clearance in at least some …
Unravelling the mechanisms of durable control of HIV-1
Untreated HIV-1 infection typically progresses to AIDS within 10 years, but less than 1% of
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …
infected individuals remain healthy and have normal CD4+ T cell counts and undetectable …
[HTML][HTML] Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design
A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic
gripping sub-Saharan Africa, but it remains elusive. A major challenge is the extreme viral …
gripping sub-Saharan Africa, but it remains elusive. A major challenge is the extreme viral …
The T-cell response to HIV
B Walker, A McMichael - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
HIV is a disease in which the original clinical observations of severe opportunistic infections
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …
HLA-B57/B* 5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong …
T Miura, MA Brockman, A Schneidewind… - Journal of …, 2009 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below
the limit of commercial assay detection (< 50 RNA copies/ml) in the absence of antiviral …
the limit of commercial assay detection (< 50 RNA copies/ml) in the absence of antiviral …
HIV-specific CD8+ T cells and HIV eradication
After the success of combination antiretroviral therapy (cART) to treat HIV infection, the next
great frontier is to cure infected persons, a formidable challenge. HIV persists in a quiescent …
great frontier is to cure infected persons, a formidable challenge. HIV persists in a quiescent …
[HTML][HTML] Focus: Infectious diseases: Mechanisms of virologic control and clinical characteristics of HIV+ elite/viremic controllers
E Gonzalo-Gil, U Ikediobi, RE Sutton - The Yale journal of biology …, 2017 - ncbi.nlm.nih.gov
Human immunodeficiency virus type 1 (HIV-1) disease is pandemic, with approximately 36
million infected individuals world-wide. For the vast majority of these individuals, untreated …
million infected individuals world-wide. For the vast majority of these individuals, untreated …
A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers
HIV-infected individuals maintaining undetectable viremia in the absence of therapy (HIV
controllers) often maintain high HIV-specific T cell responses, which has spurred the …
controllers) often maintain high HIV-specific T cell responses, which has spurred the …
CTL quality and the control of human retroviral infections
CRM Bangham - European journal of immunology, 2009 - Wiley Online Library
The CTL response plays a central part in deciding the outcome of viral infections. Evidence
from host and viral genetics, gene expression microarrays and assays of T‐cell phenotype …
from host and viral genetics, gene expression microarrays and assays of T‐cell phenotype …