Sporadic colorectal cancer has traditionally been viewed as a malignancy of older
individuals. However, as the global prevalence of the disease diagnosed in younger …

Epidemiologic data indicate a significant increase in the incidence of colorectal cancer in
younger populations in the past three decades. Moreover, recent evidence also …

Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …

Ras GTPases play a crucial role in cell signaling pathways. Mutations of the Ras gene occur
in about one third of cancerous cell lines and are often associated with detrimental clinical …

Accumulating evidence indicates an alarming increase in the incidence of early-onset
cancers, which are diagnosed among adults under 50 years of age, in the colorectum …

Simple Summary In this review, the authors will discuss the highlights of early onset colon
cancer (EOCRC), an increasing but still unclear phenomenon. Indeed, the risk factors are …

Background: Early-onset colorectal cancer (CRC), defined as diagnosis before age 50, has
increased in recent decades. Although more often diagnosed at advanced stage …

Background Colorectal cancer leads to peritoneal metastases (CRPM) in 10% of cases.
Cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC) …

With 2021 estimating 149,500 new cases and 52,980 deaths in the United States, colorectal
cancer (CRC) continues to be the third leading cause of cancer and the second leading …

Simple Summary Microsatellite stable colorectal cancer represents the majority of patients
who have been diagnosed with colorectal cancer, and it is inherently resistant to currently …