Vascular endothelial cells and innate immunity
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …
participate in both innate and adaptive immune responses. We previously reported that, in …
Circular RNAs are a novel type of non-coding RNAs in ROS regulation, cardiovascular metabolic inflammations and cancers
Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs characterized
by a covalently closed-loop structure generated through a special type of alternative splicing …
by a covalently closed-loop structure generated through a special type of alternative splicing …
[HTML][HTML] Aorta-and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways
We determined whether gut microbiota-produced trimethylamine (TMA) is oxidized into
trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes …
trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes …
[HTML][HTML] IL-35 promotes CD4+ Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms
Tregs play vital roles in suppressing atherogenesis. Pathological conditions reshape Tregs
and increase Treg-weakening plasticity. It remains unclear how Tregs preserve their function …
and increase Treg-weakening plasticity. It remains unclear how Tregs preserve their function …
ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm …
To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
Endothelial immunity trained by coronavirus infections, DAMP stimulations and regulated by anti-oxidant NRF2 may contribute to inflammations, myelopoiesis, COVID …
To characterize transcriptomic changes in endothelial cells (ECs) infected by coronaviruses,
and stimulated by DAMPs, the expressions of 1311 innate immune regulatomic genes (IGs) …
and stimulated by DAMPs, the expressions of 1311 innate immune regulatomic genes (IGs) …
[HTML][HTML] Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but …
It has been shown that anti-inflammatory cytokines interleukin-35 (IL-35) and IL-10 could
inhibit acute endothelial cell (EC) activation, however, it remains unknown if and by what …
inhibit acute endothelial cell (EC) activation, however, it remains unknown if and by what …
Non‐coding RNAs to treat vascular smooth muscle cell dysfunction
SD Brown, E Klimi, WAM Bakker… - British Journal of …, 2025 - Wiley Online Library
Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular
diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have …
diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have …
The impact of uremic toxins on vascular smooth muscle cell function
Chronic kidney disease (CKD) is associated with profound vascular remodeling, which
accelerates the progression of cardiovascular disease. This remodeling is characterized by …
accelerates the progression of cardiovascular disease. This remodeling is characterized by …
[HTML][HTML] Immuno-regenerative biomaterials for in situ cardiovascular tissue engineering–Do patient characteristics warrant precision engineering?
BJ De Kort, SE Koch, TB Wissing, MM Krebber… - Advanced Drug Delivery …, 2021 - Elsevier
In situ tissue engineering using bioresorbable material implants-or scaffolds-that harness
the patient's immune response while guiding neotissue formation at the site of implantation …
the patient's immune response while guiding neotissue formation at the site of implantation …