The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

Many protein ligands bind to heparan sulfate, which results in their presentation, protection,
oligomerization or conformational activation. Binding depends on the pattern of sulfation and …

Neural circuits consist of distinct neuronal cell types connected in specific patterns. The
specificity of these connections is achieved in a series of sequential developmental steps …

The nematode Caenorhabditis elegans is a research model organism particularly suited to
the mechanistic understanding of synapse genesis in the nervous system. Armed with …

Post-translational histone modifications play key roles in gene regulation, development and
differentiation, but their dynamics in living organisms remain almost completely unknown. To …

The extracellular matrix has emerged as an active component of chemical synapses
regulating synaptic formation, maintenance, and homeostasis. The heparan sulfate …

In the heart, glycosylation is involved in a variety of physiological and pathological
processes. Cardiac glycosylation is dynamically regulated, which remains challenging to …

Molecular imaging of glycans has been actively pursued in animal systems for the past
decades. However, visualization of plant glycans remains underdeveloped, despite that …

Glycans on the cell surfaces are essential for cellular communication. Metabolically labeling
glycans can introduce unnatural sugars into cellular glycans, which can facilitate further …

Cell-surface glycosylation contains abundant biological information that reflects cell
physiological state, and it is of great value to image cell-surface glycosylation to elucidate its …