In situ self-assembly—the in situ formation of complex materials via biochemical reactions of
monomers—has enhanced the efficacy of drug delivery for cancer therapy and imaging. So …

Protease biology is intimately linked to the functional consequences of substrate cleavage
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …

Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

During apoptosis, the mitochondrial outer membrane is permeabilized, leading to the
release of cytochrome c that activates downstream caspases. Mitochondrial outer …

Until fairly recently, proteases were considered primarily to be protein-degrading enzymes.
However, this view has dramatically changed and proteases are now seen as extremely …

Caspases are intracellular proteases that propagate programmed cell death, proliferation,
and inflammation. Activation of caspases occurs by a conserved mechanism subject to strict …

During neurodegenerative disease, the multifunctional RNA-binding protein TDP-43
undergoes a vast array of post-translational modifications, including phosphorylation …

Effective proteome-wide strategies that distinguish the N-termini of proteins from the N-
termini of their protease cleavage products would accelerate identification of the substrates …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

[Frontiers in Bioscience 13, 867-878, January 1, 2008] 867 Multiple roles of TDP-43 in gene
expression, splicing regulation, an Page 1 [Frontiers in Bioscience 13, 867-878, January 1 …