Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …

Cholangiocarcinoma is a disease entity comprising diverse epithelial tumours with features
of cholangiocyte differentiation: cholangiocarcinomas are categorized according to …

Mass-spectrometry-based proteomic profiling of human cancers has the potential for pan-
cancer analyses to identify molecular subtypes and associated pathway features that might …

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view …

1 ESGE recommends against diagnostic/therapeutic papillectomy when adenoma is not
proven. Strong recommendation, low quality evidence. 2 ESGE recommends endoscopic …

Background Upper urinary tract urothelial cancer (UTUC) may have unique etiologic and
genomic factors compared to bladder cancer. Objective To characterize the genomic …

Importance Small-bowel adenocarcinomas (SBAs) are rare cancers with a significantly
lower incidence, later stage at diagnosis, and worse overall survival than other intestinal …

Liver cancer is the second most common cause of cancer-related death. The major forms of
primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic …

Ampullary carcinomas (ACs) represent a rare entity, accounting for approximately 0.2% of all
gastrointestinal solid tumors and 20% of all periampullary cancers (PACs). Unfortunately …

Pancreatic Ductal Adenocarcinoma (PDAC) is the fourth most common cause of cancer-
related death and is the most lethal of common malignancies with a five-year survival rate …